Among the available vasoactive challenges including the injection of acetazolamide, inhalation of hypercapnic gas, and breath-holding, hypercapnia inhalation has been increasingly used in recent literature due to its potency in causing vasodilation, rapid onset and cessation of the effect, as well as recent advances in MRI-compatible gas delivery apparatus Slessarev et al., 2007 Tancredi et al., 2014 Wise et al., 2007 Yezhuvath et al., 2009). CVR is typically obtained by inducing a vasoactive challenge to the participant while monitoring changes in hemodynamic MRI signals.
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January 2023
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